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The BBB functions within the context of the neurovascular unit (McConnell et al., 2017), a structure consisting of neurons, interneurons, astrocytes, pericytes, basal lamina covered with smooth muscular cells, microglia as well as endothelial cells and extracellular matrix, and regulates the cerebral blood flow (Muoio et al., 2014)

10.1177/2050640619862721 United Eur Gastroenterol J

For context, headache rates with tirzepatide and semaglutide are similar or slightly higher, suggesting this is more of a general weight-loss medication effect than something specific to cagrilintide pharmacology

However, copper peptides should not be mixed directly with high-dose vitamin C or strong AHA/BHA formulations in the same application step, as these can chelate copper ions and reduce efficacy

Heatmap was created in ProteomeDiscoverer 2.5 (Thermo Fisher Scientific) using scaled abundance of peptide groups, Euclidean distance, Ward linkage method, and scaling before clustering