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Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes

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Within seconds of the sensing of increased reactive oxygen species (ROS), several enzymes of glycolysis (particularly glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase) are inhibiting allowing for the diversion of glucose carbons into the PPP

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[DOI] [PubMed] [Google Scholar] 6.Picca A., Calvani R., Coelho-Junior H.J., Landi F., Bernabei R., Marzetti E