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Statins have been shown in numerous studies to enhance brain BDNF by different mechanisms, including phosphorylation of Akt, glycogen synthase kinase-3 (GSK-3), and cAMP-response element-binding proteins (CREB) (Tsai, 2007
Astrocytic proBDNF and tonic GABA distinguish active versus reactive astrocytes in hippocampus
Its role in energy regulation makes it highly relevant in studies examining glucose metabolism, fatty acid oxidation, and mitochondrial function
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