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Results The volumetric glutathione production of recombinant strains individually overexpressing SER2 , SER1 , SER3 , and SER33 involved in l-Ser biosynthesis at 48 h cultivation was increased 1.3, 1.4, 1.9, and 1.9-fold, respectively, compared with that of the host GCI strain, which overexpresses genes involved in glutathione biosynthesis
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Among the agents that mediate their effects through S -glutathionylation, NOV-002 has been most extensively studied, with a phase III trial (NCT00347412) completed in advanced NSCLC [104], and data available from phase II trials in breast and ovarian cancers [105]
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doi:10.1007/s00253-023-12606-0

Tarangelo, A
