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Dynamic transcriptional responses to stress, mediated by factors like ATF4 and XBP1, also play a central role by balancing adaptive mechanisms with apoptotic pathways (Kleiber et al., 2021)

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Overcoming barriers in CAR-T therapy for neuroendocrine neoplasms CAR-T therapy faces significant challenges in solid tumors like NENs, which can be categorized into three primary areas: 1) the immunosuppressive and physically obstructive TME, 2) the scarcity of safe and homogeneously expressed tumor-specific antigens, and 3) practical limitations regarding toxicity, cost, and complex manufacturing

The process is triggered by an influx of calcium (Ca 2+ ) and bicarbonate ions

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