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Previously reported changes in the abundance of this family Prevotellaceae in advanced PD seem to have been expanded upon by Bedarf and associates, who have shown a dramatic decrease in the numbers of Prevotella copri in patients with early-stage PD (Bedarf et al., 2017)

doi: 10.2471/BLT.20.257758 26 LivakKJSchmittgenTD

Although the precise mechanisms underlying KDs effects in PD remain incompletely understood, evidence suggests that the diet can modulate glucose utilization in the brain, neurotransmitter metabolism, insulin signaling, oxidative stress, neuroinflammation, and ion channel activity, particularly potassium channels [20]

Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]

As Th17 cells appear to contribute to nigrostriatal degeneration (206, 207), the beneficial effect of T reg may be due to their ability to inhibit TH17 cells

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