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NMDA and AMPA receptors mediate intracellular calcium increase in rat cortical astrocytes

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Conover CA, Bale LK, Overgaard MT, Johnstone EW, Laursen UH, Fchtbauer EM, Oxvig C, van Deursen J

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The healthy participant population within the Simcyp simulator was modified to include ~17% intermediate CYP2D6 metabolizers and ~83% extensive CYP2D6 metabolizers based on the urinary log (dextromethorphan/dextrorphan) ratios of the clinical study participants (data not shown)

Skipping cycle breaks Running continuous cycles without breaks risks receptor desensitization