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xCT/Slc7a11 functions based on the intra- and extra- cellular gradients of cystine and glutamate in a concentration dependent manner (Briggs et al., 2016 Watanabe and Bannai, 1987)

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In an effort to identify proteins with especially oxidizable cysteine residues, proteomic studies have typically imposed millimolar concentrations of H 2 O 2 upon cells (Leichert and Jakob, 2004

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However, in pancreatic -cells the enzyme is sequestered to insulin-secretion granules in the absence of glucose

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