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doi: 10.1172/JCI115574

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Gastrointesti- nal Endocrinology

To characterize the cellular mechanism(s) involved, we determined the intracellular distribution of melanocyte-specific proteins, especially in melanin synthesis-specific organelles, termed melanosomes by subcellular fractionation followed by Western blotting and confocal laser microscopy (CFLM)

doi: 10.1371/journal.pone.0304253 73 PorcariS.BenechN.Valles-ColomerM.SegataN.GasbarriniA.CammarotaG.et al

However, the largest 24-week trial with 536 participants failed to show statistically significant weight loss, which led to development termination