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7.1Acute phase response and acute phase proteins The acute phase reaction, i.e., expression of APP such as C-reactive protein (CRP), ferritin, caeruloplasmin, fibrinogen, plasminogen, complement factors (C3, C4), procalcitonin together with the innate immune system is one of the decisive responses against damaging influences [193195]

Two of the validated antibodies can recognize transcript variants

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Chronological (Intrinsic) Aging Intrinsic or chronological aging is a natural process with the passage of time that causes inflammation with the production of reactive oxygen species (ROS) resulting in oxidative stress from cellular metabolism, which results in a loss of skin homeostasis [9, 10, 14] (Fig

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