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Keywords: Parkinsons disease, Vitamin B12, Vitamins, Homocysteine, Motor, Non-motor Introduction Parkinsons disease (PD) is a multicomplex, multi-neurotransmitter, progressive chronic disease which encompasses not only motor features (such as bradykinesia, rigidity, tremor, and gait disturbance) but also nonmotor features (including constipation, neuropathy, pain, and cognitive decline (Sauerbier et al

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It includes some heartburn medicines including proton pump inhibitors (PPIs) such as esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole, H2 blockers such as famotidine and certain diabetes medicines such as metformin

More extremely, when NAM is at an acute pharmacological dose, it is mainly converted to NAM N-oxide by CYP2E1 (Km = 2.98 mM) as quickly as possible [810]