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Active State: Wnt Ligand Binding and -Catenin Stabilization Upon Wnt ligand presence: Wnt binds the CRD of FZD and LRP5/6, forming a receptor complex

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The closest cousin is the semaglutide and Cagrilintide combination, the CagriSema concept

doi: 10.1016/j.biocel.2011.02.009
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