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The core mechanism of osteoporosis (imbalance of bone metabolism) Osteoporosis is essentially a negative balance between bone formation and bone resorption, resulting in continuous loss of bone mass, destruction of bone microstructure, increased bone fragility, and increased risk of fractures

doi: 10.3389/fcell.2025.1596421 Received 19 March 2025 Accepted 22 April 2025 Published 13 May 2025 Volume 13 - 2025 Edited by Matteo Avella, Sidra Medicine, Qatar Reviewed by Jurandy Penitente-Filho, JPF Consultoria, Brazil Qi Yin, Carnegie Institution for Science, United States Updates Copyright 2025 Gmez-Elas, Luque, Oscoz-Susino, Novero, Briski, Ksparas, Steeman, Stival, Lavolpe, Julianelli, Geller, Attie, Vassena, Krapf and Buffone

DSIP indirectly increases nocturnal GH by deepening delta-wave sleep, the phase where the largest daily GH pulse occurs

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PMID 16362768
