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Researchers introduced a ketone functional group into the erastin structure to obtain the carbonyl analog imidazole ketone erastin (IKE), which is more effective at inducing ferroptosis [128]

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By targeting beta-3 adrenergic receptors in adipose tissue and initiating metabolic cascades that enhance fat breakdown, this growth hormone fragment provides fat-reducing benefits without affecting glucose metabolism, insulin sensitivity, or IGF-1 production