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Erastin-activated ferroptosis was found to increase the levels of lysosome-associated membrane protein 2a, also known as CD107b, to promote chaperone-mediated autophagy (CMA), which in turn, promotes the degradation of GPX4

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doi: 10.1016/j.jcmgh.2022.01.022 34 GravinaA

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In the absence of an appropriate compensation by the endogenous antioxidant defense network, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause cellular damage and contribute to the late complications of diabetes [3,4]

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