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Evidence notes that metformin, a common type 2 diabetes medication, can cause a vitamin B12 deficiency

Siegel: Conceptualization, supervision, methodology, writingoriginal draft, writingreview and editing

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Evidence from rodent studies indicates that Pb exposure increases EAAT3 protein expression, potentially as a compensatory response to elevated extracellular glutamate levels [92]

VSMC proliferation and intimal thickening also predispose individuals to oscillatory or low blood flow, which have been shown to induce leukocyte adhesion, enhanced vascular permeability, LDL oxidation, and atherosclerotic plaque formation 42,43,44