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Fumarate, also an intermediate metabolite of the TCA cycle, conventionally links arginine metabolism to glucose-generated energy metabolism

However, S downregulates Sirt3 levels, which further impairs mitochondrial functions (Park et al., 2020

doi: 10.1158/1078-0432.CCR-04-0602 74 SrivastavaNBishnoiAParsadDKumaranMSVinayKGuptaS

Nature 585(7824):28892 [DOI] [PMC free article] [PubMed] [Google Scholar] 25.Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, et al

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This review provides an overview of the current knowledge of these new preservation strategies by machine perfusions and pharmacological interventions at different timing possibilities: in the organ donor, ex-vivo during perfusion machine reconditioning or after implementation in the recipient