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Jung, Y

2009;15(45):566973 Daniels, D., Grytdal, S., Wasley, A., Centers for Disease Control and Prevention (CDC)

a National Research Foundation of Korea grant, funded by the Korean government (grant numbers RS-2022-NR069719 and RS-2021-NR057690 to Y.-H.L.)

Thus, these altered metabolomic changes and perturbed balance in the motor cortex of prpTDP-43 A315T mice suggest a deficit in energy homeostasis and increased oxidative stress, events that are associated with problems with mitochondrial integrity and function

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Furthermore, elevated methylation levels of peroxisome proliferator-activated receptor gamma (PPARG) suppress its transcriptional activity, impairing adipocyte differentiation and glucose homeostasis, which contributes to the development of obesity and metabolic syndrome in PCOS patients (51)