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Notably, HR-proficient tumours are often harder to treat, owing to their intrinsic resistance to DNA-damaging agents 1

This is coupled with an exaggerated inflammatory response driven by the intestinal microbiota, leading to extensive infiltration of various immune cells, including T cells, B cells, dendritic cells (DCs), macrophages, and neutrophils, into the lamina propria

& Allaman, I

Toll-Like Receptor Signalling in the Intestinal Epithelium: How Bacterial Recognition Shapes Intestinal Function

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Similarly, track abnormalities in sweatingeither excessive, inappropriate sweating (hyperhidrosis) or a complete inability to sweat (anhidrosis) during exertion or heat exposure