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Description
When you consume a substance orally, a percentage of that substance is metabolized by the body before it can actually get into the bloodstream

Lung, heart, kidney, and plasma from cardiac puncture were collected from each animal
FeldmanELGoutmanSAPetriSMazziniLSavelieffMGShawPJet al

Clin Neuropharmacol 2013;36, 103-106

The researchers found that 10 of the liver injury cases over the last decade were attributed to turmeric combined with black pepper

2017;9(11) doi: 10.3390/nu9111224
