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doi: 10.1016/0014-2999(73)90107-6

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The results showed that acute neutrophilic inflammation and eosinophils were recruited 3 and 4 days after NiO NP instillation

Particularly, ferritin phagocytosis promoted by NCOA4, BECN1-mediated system xc inhibition, lysosomal membrane penetration induced by STAT3, and chaperon-mediated autophagy of HSP90 related molecules can all play a role in promoting ferroptosis [135]

While the preclinical safety profile appears favorable (few adverse effects reported in animal studies), this does not guarantee the same in humans, especially with prolonged use

32 Hyperglobulinemia can be seen in dogs with cirrhosis, but it remains to be determined whether this corresponds with increased autoantibodies as occurs in humans with autoimmune hepatitis, or whether it reflects nonspecific systemic antibody production in response to antigens from the portal blood which bypass the liver through acquired PSSs