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Cell Physiol 295 , C708721, (2008)

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It is a negative regulator of skeletal muscle growth Stem cell niche a microenvironment that plays an important role in keeping stem cells in quiescent state and which is indispensable for the maintenance of stem cells Sarcopenia degenerative loss of skeletal muscle mass, function, and strength associated with aging and characterized by selective type II fast fiber atrophy Notch signaling pathway a highly conserved cell signaling pathway important for cell-cell communication and control of multiple cell differentiation processes Satellite cells (SCs) Quiescent myogenic progenitor cells, which are located between the sarcolemma and basement membrane of muscle fibers Spinal and bulbar muscular atrophy (SBMA) a disorder characterized by degeneration of motor neurons in the brain stem and spinal cord