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The patient is often systemically unwell and the haemolysis may be of sufficent magnitude to cause acute renal failure

Furthermore, differentially expressed miRNAs such as rno-miR-542-3p, rno-miR-19b-3p, and rno-miR-133a-5p were identified as being centrally located in relation to differential metabolites, which included LPC 22:5, Roquefortine C, LPE 22:6, LPE 22:5, LPC 22:6, Ornithine, and LysoPE 18:2 (Fig.S3F)

Activating upstream targets of the GSH system The key upstream target for GSH system modulation is generally considered to be Nrf2, a redox-sensitive regulator

RBC-coated NPs are among the first biomimetic formulations employed (Ding et al., 2016

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