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The use of A42H13L (TABLE 1), in which one of the adjacent His residues was replaced by Leu, a substitution that would preclude any bidentate Cu 2+ ligand binding, led to results consistent with the notion that bidentate Cu 2+ ligand binding of these His residues was not essential for the oxidative damage and cellular toxicity of the native peptide (115)

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Bacillus velezensis FiA2 as an oxydifficidin-producing strain and its effects on the growth performance, immunity, intestinal microbiota, and resistance to Aeromonas salmonicida infection in Carassius carassius
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doi: 10.1192/bjp.2019.170
These spherocytes are destroyed at an increased rate because of their membrane rigidity