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Phase I reactions can have various outcomes: they may inactivate a drug, activate a pharmacologically inactive prodrug into its active form, or, in some cases, convert a non-toxic molecule into a toxic metabolite

Goossens A Systemic Contact Dermatitis to Corticosteroids

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Statins, along with inhibiting the activity of HMG-CoA reductase enzyme, also block the pathway leading to the production of CoQ10 [12, 13]

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