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The Pax7 transcription factor has been shown to be a key determinant of melanotroph identity, and it works by remodeling chromatin prior to Tpit expression, opening key areas of chromatin to allow Tpit and other transcription factors access to enhancers, resulting in melanotroph specification (13)

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GSH-depleted and control mice showed similar levels of circulating free fatty acid, triglyceride, and glycerol (Supplemental Figure 2, JL), indicating that the decreased lipid storage in liver and eWAT was not accompanied by hyperlipidemia