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Moaddel R, Zanos P, Farmer CA, Kadriu B, Morris PJ, Lovett J, et al

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

doi: 10.1513/AnnalsATS.201406-259BC

CBDs PPAR-mediated inhibition of iNOS and NLRP3 in microglia implies it could reduce neuroinflammatory NO signaling in depression These studies confirm that CBD has antidepressant effects through various mechanisms, including reducing neuroinflammation driven by iNOS, enhancing anti-inflammatory signaling mediated by PPAR, and providing neuroprotective effects that alleviate depressive behaviors

J., Lopez, R., Cole, H