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doi: 10.1016/S0140-6736(19)30427-1 4 ReijmerYDLeemansABrundelMKappelleLJBiesselsGJUtrecht Vascular Cognitive Impairment Study Group

GHK-Cu modulates fibroblast activity, guiding them towards a regenerative phenotype rather than a fibrotic one

For shRNA-based silencing of CBP, we transfected PC12-ND6 cells with the pRFP-C-RS ratSH shRNA turboRFP vectors (Origene, Rockville, MD containing either the scrambled negative control shRNA cassette (Cat # TR30015) or the rat CBP targeting shRNA FI750477 (AAGACTGTGGAGGTCAAGCCAGGAATGAA) (Cat# TF712619)

European Journal of Cell Biology

The generation of AGEs leads to associated symptoms that damage the kidney (diabetic nephropathy), retinal vasculature (diabetic retinopathy), the nerves (diabetic neuropathy), the skin, and underlying tissues (diabetic foot ulcers)