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Traditionally used in Chinese and Ayurvedic medicine, berberine has gained attention for its potential metabolic effects

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Berberine, a plant-derived alkaloid, works primarily by activating AMP-activated protein kinase (AMPK), influencing glucose and lipid metabolism

Therefore, other candidate genes or regulatory sequences on Chr21 may interfere with APP metabolism, A production, and aggregation

Evidence: Studies have shown that glucosamine provides limited improvement for joint health