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Synergistic interactions between GSTs and efflux pumps have also been observed in several studies 68,70
This finding is in agreement with previous studies demonstrating that IRS-1 levels are low or even absent in differentiating cells 37

10.1007/BF01296426 109

The second and third hotspot are known as the HGF chain, localized on blade five of the SEMA domain and immunoglobulin-plexin-transcription factor (IPT) homology domains 23, respectively

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The upregulation of VEGF by AHK-Cu might imply an enhanced potential for angiogenesis, which could influence nutrient and oxygen supply at the cellular level
