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After metabolic pathway analysis, it was found that the antidepressant mechanism of ZZCD on CUMS rats related to the improvement of brain metabolism in Phenylalanine, tyrosine and tryptophan biosynthesis, Glutathione metabolism, Phenylalanine metabolism, Lysine degradation, Cysteine, and methionine metabolism, Tyrosine metabolism, and Tryptophan metabolism

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