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This helps explain why appetite can return partly at a fixed dose and why each titration step can restore the effect

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Rare allergic reactions (particularly in individuals sensitive to sulfa, due to methionine)

The mechanisms underlying these potential synergistic effects remain under active investigation and may involve growth factor signaling, extracellular matrix synthesis, or anti-catabolic pathways in joint tissues

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Including all doses in the charts above would have made them unreadable so we eliminated similar dose-responses