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For people with normal B12 levels, taking extra B12 does not raise resting metabolic rate above its natural baseline

While so far only selected ABC transporters, including ABCB1 and ABCG2, have been studied for their role in BCL-2 inhibitor transport 66,67 , we investigated all 48 ABC transporters using an unbiased CRISPR/Cas9 screening approach in AML

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While these methods consistently point towards the regulation of NF-B and ER stress pathways, we did not perform Western blotting or use specific pathway inhibitors (e.g., NF-B inhibitors) to confirm causality at the protein level