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Osteopontin (OPN)/SPP1: from its biochemistry to biological functions in the innate immune system and the central nervous system (CNS)

A combination of stable-isotope tracers, calorimetry, hyperinsulinemic-euglycemic clamp and dynamometry were used to measure GSH synthesis, fasted and insulin-stimulated (fed) mitochondrial fuel oxidation, insulin sensitivity, body composition, anthropometry, forearm-muscle strength and lipid profiles.ResultsImpaired synthesis contributed to GSH deficiency in the patients, and was restored with cysteine plus glycine supplementation

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HMGB1/2 are essential and highly conserved regulators of genomic stability, with their functions widely reported to be modulated by lysine acetylation[41], suggesting that K-Hcy may similarly impact their biological functions (Figure S4E)

Long-term air pollution exposure and living close to busy roads are associated with COPD in women