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Gain of potential detrimental functions or effects could include: (i) increased pro-inflammatory signalling which at first is adaptive but can also be chronic and contribute to excess inflammation and degeneration 152,153

doi: 10.1016/S0378-5955(97)00130-5

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Prooxidant properties of naringenin may cause cytotoxicity to various cancer cell lines, apoptosis, and activation of one of the Mitogen-activated protein kinases, ASK1 resulting in apoptosis by ROS-mediated activation of ERK1/2 (Park et al