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Think of it as bouncer in the bar keeping the bad element out or a rivet between two sheets of tissue

185 Pyruvate kinase deficiency has a protective effect against replication of the malarial parasite in human erythrocytes.13,58 This protective effect may be related to reduced ATP levels in PK-deficient red blood cells

doi: 10.1016/j.bbadis.2011.12.009 75 FreeseC.HanadaS.Fallier-BeckerP.KirkpatrickC

Fillman SG, Cloonan N, Miller LC, Weickert CS

Ecto-5'-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature

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