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In addition to lysosomal changes, we also identified UPS system alterations in our enrichment pathway analysis, consistent with the increase in aggregated protein inclusions and the sensitivity of the DJ1 mutation cell lines to proteasome inhibition

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203210, pubmed.ncbi.nlm.nih.gov/23892832/

As a crucial second messenger within granulosa cells, MI is central to transducing FSH signals, favoring the selection of the dominant follicle, and supporting oocyte development throughout oogenesis