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However, there are no specific dosage recommendations for geriatric patients

Several factors can impair B12 absorption: Reduced stomach acid production (achlorhydria or hypochlorhydria), common in older adults and those taking proton pump inhibitors or H2-receptor antagonists long-term, impairs the release of B12 from food proteins Pernicious anaemia , an autoimmune condition destroying parietal cells and reducing intrinsic factor production, completely blocks the primary absorption pathway Gastrointestinal disorders including Crohn's disease, coeliac disease, or surgical removal of stomach or ileum sections directly damage absorption sites Metformin , commonly prescribed for type 2 diabetes, may reduce B12 absorption through unclear mechanisms

For pregnant and breastfeeding women, there isn't sufficient reliable research to confirm safety, so avoiding glutathione supplementation during these periods is generally recommended

10.3748/wjg.v22.i41.9127 [DOI] [PMC free article] [PubMed] [Google Scholar] Dobric I., Drvis P., Petrovic I., Shejbal D., Brcic L., Blagaic A

The plasma or plasma components can then be used for different medical treatments

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