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ORT is one of the most cost-effective methods of preventing excess mortality from ordinary diarrheal diseases, yet it is not utilized on a sufficient scale

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Due to the high reactivity of ROS, their excessive levels are deleterious to cells and induce different types of lesions of such macromolecules as DNA, RNA, proteins, and lipids, thereby disrupting cellular homeostasis 6 , 7

This is even more striking for a Chelator (or Cage) assembly, wherein Gid12 blocks the central space shown previously to encapsulate Fbp1, and which we find also encapsulates Mdh2 (Fig

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UpToDate, 2018