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We will examine the consequences of mtDNA dysfunction for immune cell fate and systemic inflammation, discuss the clinical relevance of mtDNA as a biomarker for toxicity and disease progression, and highlight emerging therapeutic strategies aimed at preserving mitochondrial health to improve the long-term well-being of PLWH

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10.1074/jbc.C400517200 [DOI] [PubMed] [Google Scholar] Newberry K

Translational obstacles are compounded by species- and tissue-specific differences in CL composition

Future efforts should integrate three tiers: (1) foundational research on predictive biomarkers