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It has been shown that physical activity, produces "stress" in many of these metabolic pathways, increasing the demand for these important substrates for the athlete

J Org Chem 69:58885896 [DOI] [PubMed] [Google Scholar] Foti MC, Daquino C, Geraci C (2004) Electron-transfer reaction of cinnamic acids and their methyl esters with the DPPH radical in alcoholic solutions

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Theyre not as risky as levels over 240 mg/dL but need attention

Therefore, ERGO may suppress the kynurenine pathway possibly via suppressing the CXCL9-induced activation of IDO

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