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Most clinical studies show no significant increase in blood glutathione levels from standard oral supplementation

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Int J Cancer 2002;101:710

vaso-occlusive crises in sickle cell disease or bleeding in hemophilia)

This includes vegans and vegetarians, older adults, individuals with atrophic gastritis, pernicious anemia, gastrointestinal disorders, those who have had gastrointestinal surgery and people who take certain medications including, but not limited to, estrogen (HRT), and birth control pills