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If a patient is suffering from symptoms of brain toxicity, inflammation, or other cognitive issues high dose ALA is recommended due to its remarkable abilities to improve memory, reduce brain damage, reverse cognitive dysfunction, and protect the brain from neurodegeneration

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Risk From Concomitant use with benzodiazepines or other CNS Depressants Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death

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The rationale is that EAA would serve as GST inhibitors and overcome the resistance caused by GST-dependent inactivation of the cytostatic drug

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