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Recent structural and biophysical studies have mapped the conformational ensemble of GRP94 in solution, showing that even in the presence of ATP analogs or ADP, a substantial proportion ( ~60%) of the protein remains in a persistently open V state

doi: 10.1016/j.plefa.2017.03.006, 42

After three or four freeze-thaw cycles, significant degradation has occurred

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This may help explain the worsened prognosis and increased mortality among PWH who smoke [188,189,190]

Among 218 infants that underwent neurodevelopment testing at 30 months of age, those born to mothers randomized to vitamin B 12 had higher expressive language scores than the placebo group when adjusted for baseline maternal vitamin B 12 deficiency