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Among these, the SurE cyclase, a key enzyme in the surugamide biosynthetic pathway from various Streptomyces species, is of particular interest due to its remarkable substrate tolerance, making it a promising candidate for biocatalytic applications

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Glyoxalases, the key enzymes in the detoxification of methylglyoxal, a byproduct of glycolysis and precursor of advanced glycation end-products, are compromised by oxidation and downregulation