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Due to hepatic metabolism of finasteride, precautions should be taken with patients with liver disease

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The experimental approach employed in this study including perfusion and tissue analysis without subsequent transplantation (in mouse, pig, and human models) as well as syngeneic transplantation (in rats) does not allow assessment of potential MEPS-related effects on transplant immunity

NAC has the potential to reverse the activation of the NLRP3 inflammasome as shown in, e.g., LPS-exposed H9C2 cardiomyocytes [219], in macrophages exposed to carbon nanotubes and silica [220], in bisphenol S-induced oxidative stress in murine RAW264.7 cells [221], or in cells infected by SARS-CoV-2 [222], thereby representing additional therapeutic targets for NAC

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For example, studies using CRISPR-based cytidine deaminase systems have successfully edited pathogenic mtDNA mutations in human cells, highlighting the therapeutic potential of these techniques (Schmiderer et al., 2022)