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Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

Pathogenesis An increased number of melanocytes within the basal layer of the epidermis leads to an increased production of melanin, resulting in hyperpigmented macules

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Under normal nutrient circumstances, active mTORC1 phosphorylates and sequesters Ulk1 in a complex with Atg13 and FIP200, thereby inhibiting autophagy
