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Consequently, strategies like dietary modifications, administration of probiotics, and microbiome-targeted therapies are being explored to restore gut microbial balance and mitigate disease progression 44,47

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Increased expression of BIN1 is reported in AD [17], although mechanisms behind the association of BIN1 and AD are unclear

( e ) Relative peak intensities of representative metabolites decreased in astrocytes of the 5xFAD group compared to control group, including tyrosocholic acid, sphingosine (d18:1), O-adipoylcarnitine and hexanedioic acid