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A systematic review by researchers at the University of Copenhagen cited an average of 15% bioavailability from oral melatonin, which was highly variable (range: 933%) and affected by age, illness, caffeine, smoking, and medications [296]

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Zhou, N., Chen, C., Wang, X

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Anderson CP, Tsai JM, Meek WE, Liu RM, Tang Y, Forman HJ, et al

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