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However, more recent reports fail to detect histone hypoacetylation [120], or causative transcriptional changes in the brain of young pre-symptomatic mouse [121], or even report minor gene expression alterations in key brain regions of SCA3 pathology [122]

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B12-downregulated genes in this group were related to positive regulation of transcription by RNA polymerase II, processing and transport of mRNA, mRNA splicing, cellular response to DNA damage stimulus, activation of innate immune response, positive regulation of IL-6 and IL-2 production, T-cell differentiation in thymus, histone modification, viral transcription and DNA conformational change

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Wetenschappelijke studies richten zich onder andere op de interactie met groeifactor-gerelateerde signaalroutes, extracellulaire matrixremodellering, fibroblastactiviteit, collageengerelateerde processen en de regulatie van celmigratie binnen gecontroleerde onderzoeksmodellen